Accession Number : AD0666950

Title :   TIME-RELATED ADJUSTMENTS IN ACID-BASE STATUS OF EXTRACELLULAR AND INTRACELLULAR FLUID IN CHRONIC RESPIRATORY ACIDOSIS.

Descriptive Note : Interim rept. Jan 66-Aug 67,

Corporate Author : KANSAS UNIV KANSAS CITY DEPT OF PHYSIOLOGY

Personal Author(s) : Martin,Edward D. ; Scamman,Franklin L. ; Attebery,Benjamin A. ; Brown,E. B. , Jr

Report Date : DEC 1967

Pagination or Media Count : 14

Abstract : Rats were kept in an environmental chamber in which normal oxygen pressure was maintained but in which the CO2 fraction of environmental air was 10%. From 9 to 14 animals were removed at frequent intervals during the first 36 hours and daily thereafter for 6 days in order to follow the time-related adjustments in acid-base status of extracellular and intracellular fluid in chronic respiratory acidosis. Intracellular ped from the distribution of C 14-5,5-dimethyl-2,4-oxazolidinedione (DMO) in skeletal muscle, heart, brain, and liver. Blood pH and PCO2 were measured in arterial samples drawn quickly from anesthetized animals. Extracellular water was estimated from the chloride space using Cl 36. Results indicated that skeletal muscle and extracellular fluid are buffered to nearly the same degree but that heart is better buffered and that brain was the best buffered tissue examined. Intracellular fluid of all tissue accommodated to chronic respiratory acidosis by an increase in bicarbonate, which was complete between 24 to 48 hours. This was about the same time that extracellular bicarbonate reached a new plateau value. (Author)

Descriptors :   (*ACID BASE EQUILIBRIUM, BODY FLUIDS), ACIDOSIS, RESPIRATION, CARBON DIOXIDE, PH FACTOR, MUSCLES, HEART, BRAIN, LIVER, BLOOD ANALYSIS, BICARBONATES, BUFFERS

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE