Accession Number : AD0667237

Title :   URINARY PYRIMIDINES AFTER X RADIATION,

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s) : Guri,Charles D. ; Cole,Leonard J.

Report Date : 06 FEB 1968

Pagination or Media Count : 18

Abstract : Urinary deoxycytidine and other pyrimidines were studied in rats after whole-body irradiation. Utilizing combined column and paper chromatography and colorimetric determination of the isolated CdR, significant elevations in the excretion of this compound were observed during the first 24 hours after irradiation. An increase in the plasma concentrations of CdR was also observed within 4 hours after X irradiation (100 R). Utilizing both anion and cation exchange chromatography X radiation has been shown to produce an increase in several other pyrimidines, including derivatives of the bases cytosine, thymine and uracil. While these data were suggestive of a radiation induced generalized pyrimidinuria, the urinary deoxycytidine and thymidine demonstrated remarkable elevation and were predominantly responsible for this phenomenon. (Author)

Descriptors :   (*PYRIMIDINES, *RADIATION EFFECTS), URINE, EXCRETION, DOSIMETERS, THYMIDINES, RADIATION TOLERANCE, CHROMATOGRAPHIC ANALYSIS, COLORIMETRIC ANALYSIS, X RAYS, NUCLEOSIDES, RADIATION DOSAGE

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE