Accession Number : AD0667991

Title :   THE LOCALIZATION BY ELECTRON MICROSCOPY OF SEVERAL PHOSPHATASE ACTIVITIES IN HEPATOCYTES IN CASES OF INFECTIOUS OR SERUM HEPATITIS.

Descriptive Note : Progress rept.,

Corporate Author : NARA MEDICAL COLL KASHIHARA CITY (JAPAN)

Personal Author(s) : Yasuzumi,Gonpachiro

Report Date : MAR 1968

Pagination or Media Count : 12

Abstract : It was observed that ferritin molecules are present in several patterns in hepatocytes in cases of serum or infectious hepatitis and hemosiderosis. Although production of ferritin molecules in the cells may be a specialized adaptative process, it is widely distributed through the human and animal kingdoms. It is of interest that the structure of ferritin molecules presents striking analogies to that of viruses. A ferritin molecule is composed of a protein shell, apoferritin, and a core consisting of inorganic ferric hydroxide. It is well known that viruses have shells of protein, and that they have distinct cores which contain nucleic acids. The physiological significance of the relationship between the ferritin iron and the xanthine oxidase (dehydrogenase) has been confirmed by Mazur and Carleton in the liver of the normal developing rats. Furthermore, several respiratory enzyme activities may be related to the presence of ferritin molecules. Therefore, prior to the observations on several enzyme activities of the hepatocytes in cases of serum hepatitis, ferritin patterns have been observed by means of electron microscope, x-ray microanalyzer and method of selected area microdiffraction. (Author)

Descriptors :   (*FERRITIN, MICROSTRUCTURE), LIVER, PHOSPHORIC MONOESTER HYDROLASES, CELL STRUCTURE, OXIDOREDUCTASES, INFECTIOUS HEPATITIS VIRUS, SERUM HEPATITIS, ELECTRON MICROSCOPY, ELECTRON DIFFRACTION, X RAY SPECTROSCOPY, MOLECULAR STRUCTURE, JAPAN

Subject Categories : Biochemistry
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE