Accession Number : AD0671595

Title :   STUDY OF THE PHYSIOLOGIC EFFECTS OF BLOOD PUMPS IN ANIMALS.

Descriptive Note : Annual technical progress rept. Jun 66-Jun 67.

Corporate Author : THERMO ELECTRON ENGINEERING CORP WALTHAM MASS

Report Date : JUN 1967

Pagination or Media Count : 338

Abstract : Total heart replacement pumps from the Harry Diamond Laboratories and the Avco-Kantrowitz left ventricular assist pumps were evaluated according to the following basic design: an engineering evaluation of pumps and control systems; in vitro testing of pump and controls system using a circulation analog (modified Hydrospace Mock Circulation Loop) in which Harry Diamond Laboratories pumps acted as analog right and left ventricles; and in vivo acute and chronic pump implantations in miniature swine. The acute studies (less than eight hours; animal never recovers) were designed to evaluate important hemodynamic parameters; pressure, flow, and resistance relationships, with important pump and control variables such as synchronization, timing, duration of systolic and diastolic activation, drive and filling pressures, and stroke volume. The chronic studies (more than eight hours; animal recovers) were designed to evaluate animal survival and important blood and organ function effects of mechanical pumping. (Author)

Descriptors :   (*MECHANICAL ORGANS, *HEART), PUMPS, BLOOD, PERFORMANCE(ENGINEERING), CONTROL SYSTEMS, BLOOD CIRCULATION, SURGICAL IMPLANTATION, IN VIVO ANALYSIS, BLOOD PRESSURE, SURVIVAL(PERSONNEL), IN VITRO ANALYSIS, INSTRUMENTATION, ARRHYTHMIA, BLOOD CHEMISTRY, HEMATOLOGY, PATHOLOGY, ERYTHROCYTES, OSMOSIS, HEMOLYSIS, BLOOD COAGULATION

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE