Accession Number : AD0672819

Title :   FLUOROMETRIC DETECTION OF BIOLOGIC CHANGES IN IRRADIATED LABORATORY ANIMALS.

Descriptive Note : Final rept. Oct 66-Nov 67,

Corporate Author : NORTHROP CORPORATE LABS HAWTHORNE CALIF LIFE SCIENCES LABS

Personal Author(s) : Demetriou,James A. ; Beattie,John M.

Report Date : MAY 1968

Pagination or Media Count : 30

Abstract : The excretion of fluorescent products by rodents and primates after exposure to whole-body sublethal 60Co gamma irradiation was investigated. Gel filtration chromatography and thin-layer chromatography were used to fractionate and quantitate radiation-responsive fluorescent urinary products. A major advancement in quantitating fluorescent urine products was achieved by the fluorescence-scanning of thin-layer chromatograms. Certain radiation dose-response relationships were measurable in two major fluorescent fractions from gel filtration chromatography and thin-layer chromatography of rodent and primate urine extracts within twenty-four hours postirradiation. Species variations between rodents and primates may account for different responses of fluorescent urinary products after irradiation. (Author)

Descriptors :   (*RADIOBIOLOGY, LABORATORY ANIMALS), RADIATION EFFECTS, SUBLETHAL DOSAGE, WHOLE BODY IRRADIATION, URINE, FLUORESCENCE, CHROMATOGRAPHIC ANALYSIS, PRIMATES, RODENTS

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE