Accession Number : AD0673535

Title :   A GENETIC AND BIOCHEMICAL STUDY OF DENTAL CARIES RESISTANCE.

Descriptive Note : Final technical rept. 1 May 66-30 Apr 68,

Corporate Author : INDIANA UNIV FOUNDATION BLOOMINGTON

Personal Author(s) : Bixler,David ; Merritt,A. Donald

Report Date : 20 AUG 1968

Pagination or Media Count : 32

Abstract : The purpose of this research is to define and study the inheritance pattern of the clinical condition of resistance to dental caries by (1) family studies of the resistant phenotype, (2) electrophoretic characterization of parotid and submandibular saliva from probands and immediate family members, (3) assay of antimicrobial activity of saliva from individuals in these families, and (4) correlative analysis of data from (1), (2) and (3). Evaluation was made of the dental caries status (DMFT score of none families with 138 members in which there was at least one caries free adult who met other criteria previously described. A total of 57 individuals were classified as caries-resistant, 66 were classed susceptible, 4 very susceptible and 11 could not be classified. Family pedigrees clearly show this trait to have an autosomal dominant mode of inheritance with approximately 80 per cent penetrance. Saliva and microbiologic assay studies are incomplete but it seems certain that specific biochemical information (perhaps an inherited antimicrobial protein fraction) will have to be demonstrated in order to confirm these family data. (Author)

Descriptors :   (*DENTISTRY, DISEASES), TEETH, MEDICAL RESEARCH, GENETICS, ELECTROPHORESIS, SALIVARY GLANDS, TOLERANCES(PHYSIOLOGY), SALIVA, ADULTS, BIOASSAY, CLASSIFICATION, CORRELATION TECHNIQUES

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE