Accession Number : AD0673554

Title :   STUDIES ON ANTI-TUMOR DRUGS. XX. THERAPEUTIC EFFECT AND TOXICITY OF TOTAL ALKALOIDS FROM NARCISSUS TAZETTA FROM CHANGCHOW,

Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s) : Wu,Te-cheng ; Chen,Jui-ting ; Wang,Tao-yuan ; Hsu,Pin

Report Date : 01 MAR 1966

Pagination or Media Count : 9

Abstract : The article introduces the total alkaloids (AC-445) isolated from Narcissus tazetta L. var. chinensis Roem collected from Changchow Muncipality China which has definite anti-tumor effects. Intraperitoneal injection against Jensen sarcoma in rats, and Crocker sarcoma and Ehrlich ascites carcinoma in mice, all shows distinctive therapeutic effects. Acute LD50 intraperitoneal injection of mice was found to be 182 mg/kg, and subacute LD50 of mice and rats 59 and 23 mg/kg respectively. Emesis occurred at the preliminary stage of injection of this drug, in acute toxic experiments on dogs, but ended quickly afterwards. 1, 4 and 16 mg/kg of this drug increased the leucocytes in dogs, for a long time. (Author)

Descriptors :   (*NEOPLASMS, *CHEMOTHERAPEUTIC AGENTS), (*ALKALOIDS, NEOPLASMS), THERAPY, TOXICITY, LETHAL DOSAGE, LEUKOCYTES, CHINA

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE