Accession Number : AD0674051

Title :   EFFECT OF ADENINE ON POST-TRANSFUSION SURVIVAL OF ERYTHROCYTES STORED THIRTY-FIVE DAYS.

Descriptive Note : Technical rept. Jul 66-Jul 67,

Corporate Author : VETERANS ADMINISTRATION HOSPITAL CORAL GABLES FLA*

Personal Author(s) : Peterson,Emil W. ; Newman,Harold L. ; McCarthy,William H.

Report Date : MAR 1968

Pagination or Media Count : 21

Abstract : The duration of survival of erythrocytes stored in different anticoagulants varies after transfusion. It has been known that the survival time can be increased by increasing the level of adenosine tri-phosphate in the cells and that the addition of several substances to stored blood can produce an increase of adenosine tri-phosphate and an increase in the post-transfusion survival of erythrocytes. The present study was conducted to find out whether blood stored for 35 days in acid citrate dextrose (ACD) fortified with adenine would be suitable for use in transfusion therapy. Paired autologous transfusions of erythrocytes labeled with Cr51 were given to 22 normal volunteers between 19 and 25 years of age, and chemical assays were made of the stored blood and that of the recipients after transfusion. The mean percentage of erythrocytes that survived after 24 hours for blood stored 35 days was 76.1 per cent for units with adenine compared to 50.2 per cent for units without adenine. The mean half-life for the disappearance of Cr51 from the circulating erythrocytes was 30.6 days with adenine compared to 24.0 days without adenine. No significant untoward efforts of the transfusion were noted in any subjects. The use of an adenine fortified anticoagulant in which blood is drawn and stored appears to result in increased post-transfusion survival of erythrocytes after 35 days of storage. (Author)

Descriptors :   (*ERYTHROCYTES, SURVIVAL(PERSONNEL)), ADENINE, BLOOD TRANSFUSION, ADDITIVES, ADENOSINE PHOSPHATES, ANTICOAGULANTS

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE