Accession Number : AD0674686

Title :   INVESTIGATIONS IN THE FIELD OF DIBASIC CARBOXYLIC ACIDS (ISSLEDOVANIYA V OBLASTI DVUOSNOVNYKH KARBONOVYKH KISLOT),

Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : Midzhoyan,A. L. ; Mednikyan,G. A. ; Babiyan,N. A. ; Gamburyan,A. A. ; Shakaryan,Zh. A.

Report Date : 04 OCT 1967

Pagination or Media Count : 10

Abstract : The curare-like activity of the aminoesters of succinic acid and a number of its derivatives stimulated the synthesis of new structural analogs of the widely known muscular relaxant, dithilin. In this report the homologous series of dialkylaminoethyl esters of alkylthiosuccinic acids are described. These compounds were synthesized from the acid anhydrides by their reaction with the sodium alcoholate of the amino alcohol and later with dialkylaminoethyl chloride in absolute toluene. With the exception of the methyl and butylthiohomologs the synthesized aminoesters and anhydrides of the alkylthisuccinic acids are described for the first time. The pharmacological study of the quaternary salts of the aminoesters indicated that the introduction of the alkylthio group into the acid portion of the dithilin molecule significantly reduces the curare action of dithilin. The most active are the diiodomethylates of dimethylaminoethyl esters of propyl- and amylthiosuccinic acids which do not cause changes in respiration and blood pressure during complete curarization with minimally active doses 0.25-0.5 and 0.1-0.25 mg/kg correspondingly. (Author)

Descriptors :   (*CARBOXYLIC ACIDS, MUSCLE RELAXANTS), (*MUSCLE RELAXANTS, SYNTHESIS(CHEMISTRY)), SUCCINIC ACID, SUCCINATES, AMINES, THIOLS, ANHYDRIDES, MOLECULAR STRUCTURE, DOSAGE, DITHIINS, SUBSTITUTES, DIBASIC ORGANIC ACIDS, USSR

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE