Accession Number : AD0674801

Title :   THE EFFECT OF INTRAPERITONEAL INJECTIONS OF HYPEROSMOTIC SOLUTIONS ON CONVULSIONS INDUCED BY DRUGS AND HYPERBARIC OXYGEN,

Corporate Author : DEFENCE RESEARCH ESTABLISHMENT TORONTO DOWNSVIEW (ONTARIO)

Personal Author(s) : Wood,J. D. ; Watson,W. J.

Report Date : 22 JAN 1968

Pagination or Media Count : 4

Abstract : Intraperitoneal injections of gamma-aminobutyric acid (GABA), glucose, or urea (25 mmoles/kg) prior to exposure to hyperbaric oxygen all delayed the onset of convulsions, although there were large differences in the degree of protection. GABA was the most protective agent, and at lower dosage levels (10 mmoles/kg) was the only agent to delay appreciably the onset of convulsions. An anticonvulsant effect of both GABA and glucose was observed with thiosemicarbazide but not with picrotoxin or pentylenetetrazol. Brain dehydration did not appear to play an important role in the anticonvulsant action. (Author)

Descriptors :   (*ANTICONVULSANTS, EFFECTIVENESS), GLUCOSE, UREA, OXYGEN, PROTECTION, OSMOSIS, PRESSURE BREATHING, CONVULSIVE DISORDERS, TOXICITY, DOSAGE, SOLUTIONS(MIXTURES), INJECTIONS(MEDICINE), PERITONEUM, AMINO ACIDS, CANADA

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE