Accession Number : AD0675756

Title :   SYNTHESIS OF SOME 1,4-NAPHTHOQUINONES AND REACTIONS RELATING TO THEIR USE IN THE STUDY OF BACTERIAL GROWTH INHIBITION,

Corporate Author : DEFENCE RESEARCH ESTABLISHMENT SUFFIELD RALSTON (ALBERTA)

Personal Author(s) : Silver,R. F. ; Holmes,H. L.

Report Date : 08 AUG 1967

Pagination or Media Count : 7

Abstract : A series of 107 1,4-naphthoquinones and related products has been synthesized to study their mode of action in bacterial growth inhibition. The in vitro reactions of a number of these with aniline, n-butylamine, sodium methoxide, and an n-buthanethiol - triethylamine mixture have been examined. A series of epoxides of C-2 monosubstituted and C-2, C-3 disubstituted 1,4-naphthoquinones has been synthesized and their reactions with amines, thiols, and halogen acids have been studied. The ultraviolet absorption maxima of many of these quinones are also tabulated. (Author)

Descriptors :   (*QUINONES, SYNTHESIS(CHEMISTRY)), (*ANTIMETABOLITES, QUINONES), STAPHYLOCOCCUS AUREUS, IN VITRO ANALYSIS, AMINES, THIOLS, HALOGENS, CHEMICAL REACTIONS, ULTRAVIOLET SPECTROSCOPY, TABLES(DATA), CANADA

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE