Accession Number : AD0676143

Title :   METABOLIC EFFECTS OF LONG-TERM EXPOSURE OF DOGS TO A PARTIAL PRESSURE OF 60 MM. HG CO2.

Descriptive Note : Final rept. Sep 66-May 67,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Pepelko,William E.

Report Date : JUN 1968

Pagination or Media Count : 12

Abstract : Six male mongrel dogs implanted with either arterial or venous catheters were exposed to a partial pressure of 60 mm. Hg CO2 for 10 days. Daily fasting plasma glucose and free fatty acid (FFA) levels did not differ significantly from control levels. Glucose tolerance after intravenous injection of 1 gm. of glucose/kg. body weight was decreased below that of controls on the first day of exposure to high CO2. After 7 to 8 days of exposure, glucose tolerance increased to that of controls. Weight loss averaged 1.7 lb. during the 10-day exposure to high CO2 and 0.6 lb. during a 10-day control period. The dogs ate normally throughout the experimental period. In general, they appeared to adapt quite well, with the measurements of plasma FFA and glucose indicating a minimum of stress. (Author)

Descriptors :   (*CARBON DIOXIDE, TOXICITY), GLUCOSE, BLOOD, TOXIC TOLERANCES, FATTY ACIDS, BLOOD CHEMISTRY, PARENTERAL INFUSIONS, STRESS(PHYSIOLOGY), ADAPTATION(PHYSIOLOGY)

Subject Categories : Stress Physiology
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE