Accession Number : AD0676145

Title :   DETERMINATION OF FIVE BLOOD PARAMETERS USING 59FE.

Descriptive Note : Rept. for Nov 67-Jan 68,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Logsdon,Donald F. , Jr. ; Green,James F.

Report Date : JUN 1968

Pagination or Media Count : 10

Abstract : A simplified method for determining the clearance of iron from plasma, the uptake of iron by newly formed red cells, the direct measurement of plasma volume, and the indirect measurement of volume and red cell mass, was achieved by modification and synthesis of existing methods. Typical values obtained were: plasma iron clearance (T-1/2), 100 minutes; red cell iron incorporation, 80% to 85% within 8 days; 59Fe plasma volume, 41.5 ml./kg.; 59Fe blood volume, 72.4 ml./kg.; and 59Fe red cell volume, 32.7 ml./kg. The values obtained were within the limits of values previously reported as obtained by other methods. These measurements, combined with values calculated for other iron metabolic factors, provide the basis for reliable estimates of ferrokinetics and iron metabolism under normal and abnormal conditions. (Author)

Descriptors :   (*IRON, *METABOLISM), (*RADIOACTIVE ISOTOPES, *BLOOD ANALYSIS), BLOOD VOLUME, ERYTHROCYTES, GAMMA RAY SPECTROSCOPY, BLOOD CHEMISTRY

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE