Accession Number : AD0676146

Title :   GLUCOSE TOLERANCE IN DOGS EXPOSED TO ALTITUDE AND DRUG ADMINISTRATION: AMPHETAMINE.

Descriptive Note : Rept. for Sep-Oct 67,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Taub,Martin ; Bernardini,Albert T.

Report Date : JUN 1968

Pagination or Media Count : 11

Abstract : This study was initiated to determine the effect of altitude and drug administration on glucose tolerance at altitude. Dogs were exposed to a simulated altitude of 27,000 ft. and the rate of disappearance of intravenously injected glucose (0.5 gm./kg.) was compared with similar tests at ground level. All dogs were maintained on the same PO2 in the inspired air (152 mm. Hg PO2). In addition, amphetamine (1 mg./kg. I.V.) was administered to the dogs under both atmospheric conditions. A significant increase was seen in the K-value of the nondrug dogs exposed to simulated altitude (P less than .01). Also, a significant increase in the K-value was noted in the dogs treated with amphetamine at ground level as compared with ground-level controls (P less than .01). The K-value of dogs exposed to altitude and administered amphetamine was significantly raised (P less than .01) as compared with both ground-level and altitude nondrug conditions. (Author)

Descriptors :   (*TOXIC TOLERANCES, *HIGH ALTITUDE), AMPHETAMINES, GLUCOSE, BLOOD, OXYGEN, PRESSURE, BLOOD CHEMISTRY, DRUGS

Subject Categories : Stress Physiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE