Accession Number : AD0677126

Title :   GROWTH-INHIBITORY ACTIVITIES OF SOME 1,4-NAPHTHOQUINONES AND RELATED COMPOUNDS ON STAPHYLOCOCCUS AUREUS AND ESCHERICHIA COLI.

Descriptive Note : Technical paper,

Corporate Author : DEFENCE RESEARCH ESTABLISHMENT SUFFIELD RALSTON (ALBERTA)

Personal Author(s) : Leahy,G. J. ; Currie,D. J. ; Holmes,H. L. ; Maltman,J. R.

Report Date : 20 JUL 1967

Pagination or Media Count : 7

Abstract : Growth-inhibitory activities of some or all of 98 1,4-naphthoquinones and 16 related compounds on Escherichia coli and two strains of Staphylococcus aureus were determined alone or in combination. These values, when plotted against their polarographic half-wave potentials and those of their C2-n-butylthio analogs support the hypothesis that these compounds, or the products resulting from their reaction with a protein nucleophile, function by short-circuiting one or other of the quinones present in the electron-transport chain. (Author)

Descriptors :   (*MICROORGANISMS, ANTIMETABOLITES), (*QUINONES, *ANTIMETABOLITES), ESCHERICHIA COLI, STAPHYLOCOCCUS AUREUS, CURVE FITTING

Subject Categories : Microbiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE