Accession Number : AD0677126
Title : GROWTH-INHIBITORY ACTIVITIES OF SOME 1,4-NAPHTHOQUINONES AND RELATED COMPOUNDS ON STAPHYLOCOCCUS AUREUS AND ESCHERICHIA COLI.
Descriptive Note : Technical paper,
Corporate Author : DEFENCE RESEARCH ESTABLISHMENT SUFFIELD RALSTON (ALBERTA)
Personal Author(s) : Leahy,G. J. ; Currie,D. J. ; Holmes,H. L. ; Maltman,J. R.
Report Date : 20 JUL 1967
Pagination or Media Count : 7
Abstract : Growth-inhibitory activities of some or all of 98 1,4-naphthoquinones and 16 related compounds on Escherichia coli and two strains of Staphylococcus aureus were determined alone or in combination. These values, when plotted against their polarographic half-wave potentials and those of their C2-n-butylthio analogs support the hypothesis that these compounds, or the products resulting from their reaction with a protein nucleophile, function by short-circuiting one or other of the quinones present in the electron-transport chain. (Author)
Descriptors : (*MICROORGANISMS, ANTIMETABOLITES), (*QUINONES, *ANTIMETABOLITES), ESCHERICHIA COLI, STAPHYLOCOCCUS AUREUS, CURVE FITTING
Subject Categories : Microbiology
Distribution Statement : APPROVED FOR PUBLIC RELEASE