
Accession Number : AD0677924
Title : ANALYSIS OF THE RADIATIONINDUCED LOSS OF TESTES WEIGHT IN TERMS OF STEM CELL SURVIVAL,
Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF
Personal Author(s) : Krebs,John S.
Report Date : 18 SEP 1968
Pagination or Media Count : 22
Abstract : The proportion of radiationinsensitive tissue in the testes of the C57L mouse was determined to be 36.9% of the normal nonirradiated testes weight. The weights of testes of these mice at 28 days after various doses of irradiation were analyzed by subtracting out the radiationinsensitive weight and calculating the surviving fraction (S/So) of radiationsensitive weight. The logarithm of S/So could be fitted linearly to the radiation dose, indicating an exponential tissueloss process with a D37 for 250 KVp Xrays of 78.9 rad. The D37 for testes weight loss from sissionneutron irradiation was 21.0 rad, indicating a relative biological effectiveness ratio (R.B.E.) for fission neutrons of 3.75. Treatment of mice with AET (2aminoethylisothiouronium bromide hydrobromide) 15 minutes before irradiation with Xrays increased the D37 to 119.6 rad, indicating a protection ratio of 1.5 for AET. Treatment of mice with Piromen (pseudomonas polysaccharide) 24 hours before irradiation had no effect on the D37 for testes weight loss. Irradiation with Xrays at 2.8 R/min gave the same D37 for testes weight loss as irradiation at 14 R/min. The data indicate that loss of weight of the testes after irradiation reflects the survival curve of the germinal cell layer of the testes. (Author)
Descriptors : (*TESTES, *RADIATION EFFECTS), NEUTRONS, X RAYS, DOSE RATE, RADIATION INJURIES, WEIGHT, SENSITIVITY, RADIOBIOLOGY, RADIOPROTECTIVE AGENTS
Subject Categories : Radiobiology
Distribution Statement : APPROVED FOR PUBLIC RELEASE