Accession Number : AD0678491

Title :   PARALYZING ANIMAL POISONS.

Descriptive Note : Yearly technical rept.,

Corporate Author : AMSTERDAM UNIV (NETHERLANDS)

Personal Author(s) : VAN DER Meer,C. ; Drenth,D. ; Piek,T. ; Thomas,R. T. Simon ; Spanjer,W.

Report Date : SEP 1968

Pagination or Media Count : 33

Abstract : It was shown that in stimulated muscles the decrease in frequency of the miniature potentials runs parallel to the decrease in postsynaptic potential as well as to the decrease in muscle contraction. This clearly indicates that Microbracon venom causes paralysis of the neuromuscular system by acting at a presynaptic site. Philanthus venom inhibits the fast as well as the slow neuromuscular system at identical concentrations. It causes a decrease in the frequency of the miniature potentials without affecting their amplitude significantly. This indicates that Philanthus venom also acts at a presynaptic site. The inhibitory neuromuscular system of the m. adductor coxae of Schistocerca has been investigated extensively preparatory to a study of the effect of Philanthus venom on this system. During this investigation hyperpolarizing miniature potentials (MIPSP's) have been discovered. Anoplius venom was subjected to a preliminary study. Indications were found that it may be specific for spiders (or a few species of spiders) and that it may have a central action. Its action proved to be reversible. The molecular weight of Microbracon venom was estimated at about 65,000. Proteolytic enzymes destroy the biological activity. Using column electrophoresis on polyacrylamide gel, a considerable purification of the active component of Microbracon venom could be obtained. A very marked purification of Philanthus venom was obtained using different types of Sephadex. Its molecular weight could be estimated at less than 700. This venom appears to be very stable. (Author)

Descriptors :   (*ANIMALS, POISONS), PARALYSIS, ELECTROPHYSIOLOGY, MUSCLES, CONTRACTION, TOXICITY, INSECTS, VENOMS, MOLECULAR WEIGHT, NERVES, END ORGANS, NEUROMUSCULAR TRANSMISSION, NERVE CELLS

Subject Categories : Anatomy and Physiology
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE