Accession Number : AD0678605

Title :   ANALYSIS OF THE MECHANISM OF ACTION OF THE NERVE GROWTH FACTOR.

Descriptive Note : Final rept.,

Corporate Author : WASHINGTON UNIV ST LOUIS MO DEPT OF BIOLOGY

Personal Author(s) : Levi-Montalcini,Rita

Report Date : JUL 1968

Pagination or Media Count : 7

Abstract : The research project carried out during the last two years has been centered on the study of the nerve growth factor (NGF). This is a unique protein endowed with growth promoting activity on embryonic sensory and embryonic and mature sympathetic nerve cells. Our investigations centered on the study of the following aspects of the problem: Analysis of the nerve growth effect on the receptive nerve cells at the ultrastructural level. Analysis of the early ultrastructural changes in sympathetic nerve cells following antiserum treatment. Study of the biosynthesis of the NGF in the mouse submaxillary salivary glands. Comparative studies of NGF purified from snake venom and mouse salivary glands. Conformational changes of a specific brain protein. (Author)

Descriptors :   (*NERVE CELLS, GROWTH(PHYSIOLOGY)), EMBRYOS, END ORGANS, AUTONOMIC NERVOUS SYSTEM, BIRTH, IN VITRO ANALYSIS, NERVE FIBERS, CULTURE MEDIA, IN VIVO ANALYSIS, LABORATORY ANIMALS, GANGLIA, SALIVARY GLANDS, BIOSYNTHESIS, BRAIN, PROTEINS

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE