Accession Number : AD0678646

Title :   DEPOLARIZATION OF THE NEURALLY BLOCKED GASTRIC MUCOSA OF THE RAT,

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s) : Cummins,Joseph T. ; Vaughan,Burton E. ; Pessotti,Rita L.

Report Date : 23 SEP 1968

Pagination or Media Count : 19

Abstract : The effects of brief alternating and square wave currents on gastric bioelectric activity and acid secretion were studied at frequencies between 10 and 10000 cycles/sec. Whereas acid secretion remains unchanged, potential and conductance are inversely affected by both wave forms, indicating a depolarization of the epithelium. Excitation conditions allowing optimal recovery from pulsing (100 cycles/sec and 10 V) are similar to those required to affect other preparations like squid axon and brain or muscle slices. Isolated mucosa requires less power for the same response as occurs in whole stomach. Electrical pulses apparently act directly on the mucosal membranes since neither atropine (0.001 M) nor TTX (1.6 x 000001 M) will block the depolarization effect. Unlike atropine, TTX still permits the standard response caused by 0.01 M Ach, namely inhibition of potential without conductance increase. (Author)

Descriptors :   (*TISSUES(BIOLOGY), ELECTROPHYSIOLOGY), STOMACH, ATROPINE, STIMULATION(PHYSIOLOGY), RATS, ACIDS, SECRETION, NERVES, CONDUCTIVITY, MEMBRANES(BIOLOGY), POLARIZATION, TABLES(DATA), PERMEABILITY

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE