Accession Number : AD0679404

Title :   ISOLATION AND STRUCTURES OF 1,2,3,4-TETRAHYDRO-1,4-DIOXOPYRAZINO(1,2-A)-INDOLES FROM CULTURES OF PENICILLIUM TERLIKOWSKII,

Corporate Author : NATIONAL RESEARCH COUNCIL OF CANADA HALIFAX (NOVA SCOTIA) ATLANTIC REGIONAL LAB

Personal Author(s) : Ali,M. S. ; Shannon,J. S. ; Taylor,A.

Report Date : 25 MAR 1968

Pagination or Media Count : 6

Abstract : Cultures of Penicillium terlikowskii have been examined for the presence of 1,2,3,4-tetrahydro-1,4-dioxopyrazino(1,2-a)indoles, as there are theoretical reasons for these being intermediates in the biosynthesis of antibiotics like gliotoxin. Four fractions have been isolated from cultures of the fungus with the required properties, and the structures of three crystalline metabolites obtained therefrom have been determined. One of these has the structure postulated for the biosynthetic intermediate of gliotoxin. A number of tetrahydro1,4-dioxopyrazino(1,2-a)indoles have been synthesised during this work; these syntheses and the physical properties of the compounds are given. (Author)

Descriptors :   (*INDOLES, *PENICILLIUM(PENICILLINS)), (*MOLECULAR STRUCTURE, INDOLES), CULTURE MEDIA, METABOLISM, SYNTHESIS(CHEMISTRY), ULTRAVIOLET SPECTRA, VISIBLE SPECTRA, CHROMATOGRAPHIC ANALYSIS, CANADA

Subject Categories : Biochemistry
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE