Accession Number : AD0679675

Title :   RETARDED IMMUNOLOGICAL RECOVERY IN SUBLETHALLY X-IRRADIATED MICE BY ADDITIONAL THYMIC EXPOSURE. REVERSAL WITH INJECTED MARROW CELLS,

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s) : Davis,William E. , Jr. ; Cole,Leonard J.

Report Date : 24 OCT 1968

Pagination or Media Count : 20

Abstract : The role of the intact thymus in recovery of the immune response following a sublethal dose of X radiation was studied. Groups of adult LAF1 mice were exposed to 500 rad of X rays and some of these animals, appropriately lead-shielded, then received an additional 500, 1000, or 2000 rad to the thymic area through a 1.2 cm diameter shield opening. Three criteria of immunological response were employed: (1) numbers of Jerne antibody plaque-forming cells (PFC) in the spleen; (2) concentration of antigen-reactive cells (ARC); (3) rejection time of skin homografts. (Author)

Descriptors :   (*IMMUNOLOGY, RADIATION EFFECTS), (*THYMUS, *RADIATION EFFECTS), X RAYS, MICE, ANTIGEN ANTIBODY REACTIONS, SPLEEN, SKIN(ANATOMY), TRANSPLANTATION, BONE MARROW, CELLS(BIOLOGY), TISSUES(BIOLOGY), THERAPY, RECOVERY

Subject Categories : Medicine and Medical Research
      Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE