Accession Number : AD0680227
Title : PROMISING RESEARCH AREAS-I. A STUDY OF THE BIOLOGICAL EFFECTS OF CHEMICAL SUBSTANCES EMPLOYING THE CONCEPTS AND TECHNIQUES OF PHYSICAL CHEMISTRY.
Descriptive Note : Technical rept.,
Corporate Author : FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY BETHESDA MD
Personal Author(s) : McManus,J. F. A.
Report Date : NOV 1968
Pagination or Media Count : 67
Abstract : This report summarizes recent investigations that relate physical changes in macromolecular protein structures to biological functions. It is based on a review by scientists studying protein structure changes induced by van der Waals forces; model cell membrane systems that measure the functions of the enzyme permeases; the biological applications of nuclear magnetic resonance and electron spin resonance spectra and spin-labeling techniques; fluorescence spectra, polarization and decay times, and absorption spectroscopy as indicators of biological events; and the significance of molecular geometric changes in a series of biologically active compounds as related to their chemical structure. The topics include the nature of changes produced by chemicals at cell surfaces, enzyme-substrate interactions, novel concepts of charge transport through biological substrates, and their relationship to fine-structure changes in living systems. (Author)
Descriptors : (*MEDICAL RESEARCH, PREDICTIONS), (*BIOCHEMISTRY, MEDICAL RESEARCH), MOLECULAR PROPERTIES, MOLECULAR SPECTROSCOPY, FLUORESCENCE, CHEMICAL REACTIONS, ANESTHETICS, MEMBRANES(BIOLOGY), POLARIZATION, XENON, PHYSICAL CHEMISTRY, PROTEINS
Subject Categories : Biochemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE