Accession Number : AD0680227

Title :   PROMISING RESEARCH AREAS-I. A STUDY OF THE BIOLOGICAL EFFECTS OF CHEMICAL SUBSTANCES EMPLOYING THE CONCEPTS AND TECHNIQUES OF PHYSICAL CHEMISTRY.

Descriptive Note : Technical rept.,

Corporate Author : FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY BETHESDA MD

Personal Author(s) : McManus,J. F. A.

Report Date : NOV 1968

Pagination or Media Count : 67

Abstract : This report summarizes recent investigations that relate physical changes in macromolecular protein structures to biological functions. It is based on a review by scientists studying protein structure changes induced by van der Waals forces; model cell membrane systems that measure the functions of the enzyme permeases; the biological applications of nuclear magnetic resonance and electron spin resonance spectra and spin-labeling techniques; fluorescence spectra, polarization and decay times, and absorption spectroscopy as indicators of biological events; and the significance of molecular geometric changes in a series of biologically active compounds as related to their chemical structure. The topics include the nature of changes produced by chemicals at cell surfaces, enzyme-substrate interactions, novel concepts of charge transport through biological substrates, and their relationship to fine-structure changes in living systems. (Author)

Descriptors :   (*MEDICAL RESEARCH, PREDICTIONS), (*BIOCHEMISTRY, MEDICAL RESEARCH), MOLECULAR PROPERTIES, MOLECULAR SPECTROSCOPY, FLUORESCENCE, CHEMICAL REACTIONS, ANESTHETICS, MEMBRANES(BIOLOGY), POLARIZATION, XENON, PHYSICAL CHEMISTRY, PROTEINS

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE