Accession Number : AD0680403

Title :   MEASURING IRON METABOLISM IN HEMATOPOIETIC CENTERS USING 59Fe IN THE PRESENCE OF 51Cr AND 125I.

Descriptive Note : Rept. for Jan-Mar 68,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Strong,Guy M. ; Logsdon,Donald F. ; Green,James F.

Report Date : SEP 1968

Pagination or Media Count : 12

Abstract : The 59Fe concentration in the hematopoietic centers (sacrum, liver, and spleen) can be accurately and reproducibly determined with a rate meter, a photomultiplier probe, and a scintillation crystal detection system. When the three isotopes 51Cr, 125I, and 59Fe are present, a 10 mm. lead filter screens out essentially all of the chromium and iodine isotope activity while allowing 60% of the 59Fe activity to pass. The use of a constant standard and the calculation of the R factor (area of radiation site/area of standard) makes decay correction unnecessary. Since iron metabolism is normally measured as part of a larger study of erythrokinetics and blood parameters, this technic allows two or more isotope studies of hematopoietic centers to be conducted simultaneously. (Author)

Descriptors :   (*IRON, *METABOLISM), (*RADIOBIOLOGY, METABOLISM), LIVER, SPLEEN, HEMOGLOBIN, RADIOACTIVE ISOTOPES, CHROMIUM, IODINE, SCINTILLATION COUNTERS

Subject Categories : Anatomy and Physiology
      Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE