Accession Number : AD0681501

Title :   THE EFFECT OF HIGH CONCENTRATIONS OF CARBON DIOXIDE ON BLOOD SEROTONIN LEVELS IN MAN. CHRONIC HYPERCAPNIA.

Descriptive Note : Rept. for 17 Nov-7 Dec 67,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Gordon,Edward D. , Jr

Report Date : SEP 1968

Pagination or Media Count : 14

Abstract : Whole blood serotonin levels in young men were investigated during exposure to a 4% carbon dioxide environment (PICO2 = 29.9 mm. Hg) for a 10-day period. No significant change in serotonin levels was found in those men acting as outside controls at ambient (0.03%) carbon dioxide, but there was a 34.0% decrease (P < .01) of serotonin levels in men exposed to 4% carbon dioxide. Exposure to 4% carbon dioxide produced throbbing headaches (day 1-2) and nausea (day 4-6). Serotonin levels after an initial depression tended to return to control levels during the 4% carbon dioxide exposure period. Observed correlation between carbon dioxide and serotonin suggests that the role of carbon dioxide in control of cerebral circulation may be mediated through serotonin. (Author)

Descriptors :   (*CARBON DIOXIDE, STRESS(PHYSIOLOGY)), (*BLOOD CHEMISTRY, *SEROTONIN), BLOOD CIRCULATION, PH FACTOR, RESPIRATORY SYSTEM

Subject Categories : Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE