Accession Number : AD0682285

Title :   STRESS RESPONSE AS A PREDICTOR OF RADIOSENSITIVITY IN PRIMATES,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Hamilton,Horace E. ; Melville,George S. , Jr

Report Date : NOV 1968

Pagination or Media Count : 12

Abstract : Macaca mulatta primates were standardized and then subjected to stress in the form of prolonged breathing of an air atmosphere saturated with ethanol vapor. Significant changes (P < .01) were noted in their urine volumes and the excretion of electrolytes and 17-hydroxycorticoids. The primates were then irradiated with a lethal dose (1,100 R) of gamma radiation. Their survival times were recorded and tested for correlation with body weights, urine volumes, excretion of electrolytes and corticoids, and post-stress blood alcohol levels. The changes in the Na/K urinary ratio were found to be significantly (P < .01) related to the respective postirradiation survival times, but no significant correlation between survival time and the other measurements was detected. (Author)

Descriptors :   (*RADIATION TOLERANCE, STRESS(PHYSIOLOGY)), ELECTROLYTES, EXCRETION, ETHANOLS, CORTICOSTEROID AGENTS, LETHAL DOSAGE, GAMMA RAYS, BODY WEIGHT, URINE, TABLES(DATA), RADIOBIOLOGY, MONKEYS

Subject Categories : Anatomy and Physiology
      Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE