Accession Number : AD0683308

Title :   GASTRIC MUCOSA AFTER IRRADIATION. I. EVIDENCE FOR NEURAL AND PERMEABILITY CHANGES AFFECTING ELECTRICAL POLARIZATION AT 4 HOUR AND 170 HOUR,

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s) : Vaughan,Burton E. ; Pessotti,Rita L.

Report Date : 12 DEC 1968

Pagination or Media Count : 18

Abstract : Recent work has permitted separation of an intact mucosa from isolated stomach of irradiated rats, and these preparations show several important differences from previous studies. Four hours after irradiation, mucosas showed 30% elevation in transmural potential due to an inhibition of the normally tonic cholinergic excitation of this separated epithelium. Other factors which could directly alter the transmural electrical potential remained essentially constant; for example tissue permeability as determined by electrical conductance, and the sensitivity of the cholinergic effector system to acetylcholine. By contrast, mucosas 170 hours after irradiation showed no change in potential and a consistent increase in permeability (conductance) of about 17%. In addition, they showed much greater reactivity toward acetylcholine, compared to nonirradiated mucosas. The changes observed after 170 hours are attributable to a decreased tissue thickness and they adequately explain earlier findings, showing seventh day inhibition of electrical activity in isolated, irradiated whole stomach. (Author)

Descriptors :   (*RADIATION EFFECTS, *STOMACH), NERVES, ACETYLCHOLINE, MUSCLES, PERMEABILITY, INHIBITION, SENSITIVITY, AUTONOMIC NERVOUS SYSTEM, POLARIZATION

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE