Accession Number : AD0683350
Title : CEREBRAL CORTEX PRINCIPLES INHIBITING THE PITUITARY-ADRENAL AXIS.
Descriptive Note : Final scientific rept. 1 Dec 67-30 Nov 68,
Corporate Author : MILAN UNIV (ITALY) ISTITUTO DI FARMACOLOGIA E DI TERAPIA
Personal Author(s) : Martini,L.
Report Date : 27 DEC 1968
Pagination or Media Count : 7
Abstract : It was shown that Cerebral Cortex of several mammals contains one or more principles which is/are able to inhibit the pituitary-adrenal axis of the rat. The purification of calf cerebral cortices has given yield to a material which is active at the dose of a few micrograms. Cerebral Cortex principles are able (a) to block the 4.00 p.m. rise in plasma corticosterone in normal rats; (b) to bring back to normal the elevated plasma corticosterone levels which are found in midbrain-sectioned animals and (c) to counteract the activating effect on the pituitary-adrenal axis of 'neurogenic' stresses. (Author)
Descriptors : (*CEREBRAL CORTEX, CORTICOSTEROID AGENTS), INHIBITION, PURIFICATION, ADRENAL GLANDS, RATS, BLOOD PLASMA, PITUITARY GLAND, CHROMATOGRAPHIC ANALYSIS, ELECTROPHORESIS, INJECTIONS(MEDICINE), DOSAGE, ITALY
Subject Categories : Anatomy and Physiology
Distribution Statement : APPROVED FOR PUBLIC RELEASE