Accession Number : AD0683350

Title :   CEREBRAL CORTEX PRINCIPLES INHIBITING THE PITUITARY-ADRENAL AXIS.

Descriptive Note : Final scientific rept. 1 Dec 67-30 Nov 68,

Corporate Author : MILAN UNIV (ITALY) ISTITUTO DI FARMACOLOGIA E DI TERAPIA

Personal Author(s) : Martini,L.

Report Date : 27 DEC 1968

Pagination or Media Count : 7

Abstract : It was shown that Cerebral Cortex of several mammals contains one or more principles which is/are able to inhibit the pituitary-adrenal axis of the rat. The purification of calf cerebral cortices has given yield to a material which is active at the dose of a few micrograms. Cerebral Cortex principles are able (a) to block the 4.00 p.m. rise in plasma corticosterone in normal rats; (b) to bring back to normal the elevated plasma corticosterone levels which are found in midbrain-sectioned animals and (c) to counteract the activating effect on the pituitary-adrenal axis of 'neurogenic' stresses. (Author)

Descriptors :   (*CEREBRAL CORTEX, CORTICOSTEROID AGENTS), INHIBITION, PURIFICATION, ADRENAL GLANDS, RATS, BLOOD PLASMA, PITUITARY GLAND, CHROMATOGRAPHIC ANALYSIS, ELECTROPHORESIS, INJECTIONS(MEDICINE), DOSAGE, ITALY

Subject Categories : Anatomy and Physiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE