Accession Number : AD0683501

Title :   PRESERVATION OF HUMAN BLOOD FROM MALE AND FEMALE DONORS.

Descriptive Note : Interim rept.,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : DeVenuto,Frank ; Wilson,Harold L. ; Morse,Sarah S. ; Ligon,Dorothy F.

Report Date : 12 NOV 1968

Pagination or Media Count : 18

Abstract : Units of human blood were obtained from male and female donors and compared for changes in pH, ATP levels, in vitro spontaneous hemolysis, hexokinase activity, G-6-PD levels and osmotic resistance during storage in ACD for a period up to 42 days. The data show that, by the criteria of the above determinations, the blood obtained from female donors is better able to survive the storage lesions than the blood from male donors. These results are attributed to the different endocrine systems in the human male and female and the capacity to form structurally and pharmacologically different endogenous steroid hormones. The possibility that these steroid hormones could interact with components of the red cell membrane and limit an increase in cell membrane permeability is discussed. A sample of blood obtained from an 8-month pregnant human female was also studied; the pattern of preservation of such blood was essentially the same as that observed with the blood of female donors. (Author)

Descriptors :   (*BLOOD, PRESERVATION), BLOOD CHEMISTRY, STORAGE, MALES, FEMALES, ENDOCRINE GLANDS, STEROIDS, HORMONES, CELL WALL, MEMBRANES(BIOLOGY), PERMEABILITY, HEMOLYSIS, IN VITRO ANALYSIS, HUMANS

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE