Accession Number : AD0684215

Title :   THE EFFECT OF ERYTHROPOIETIN ON SURVIVAL IN IRRADIATED POLYCYTHEMIC MICE,

Corporate Author : DEFENCE CHEMICAL BIOLOGICAL AND RADIATION ESTABLISHMENT OTTAWA (ONTARIO)

Personal Author(s) : Vittorio,P. V. ; Watkins,E. A. ; Dziubalo-Blehm,S.

Report Date : 27 SEP 1968

Pagination or Media Count : 4

Abstract : In mice in which polycythemia was induced by transfusion, stem cell activity was almost completely suppressed, and this was accompanied by increased resistance to radiation since survival studies showed the polycythemic mouse to be more resistant to radiation than the normal mouse. The stimulation of stem cell activity in the polycythemic mouse with the humoral factor erythropoietin produced an increase in radiation sensitivity, as measured by survival studies. This was then followed by a more radioresistant phase as stem cell activity slowed down. Thus, in the polycythemic mouse, changes in radiation sensitivity can be brought about by a change in the state of the stem cell compartment at the time of irradiation. (Author)

Descriptors :   (*RADIATION EFFECTS, *BLOOD DISEASES), RESISTANCE(BIOLOGY), SURVIVAL(PERSONNEL), RADIATION TOLERANCE, RADIATION DOSAGE, SENSITIVITY, BLOOD CELLS, STIMULATION(PHYSIOLOGY), RESPONSE(BIOLOGY), CANADA

Subject Categories : Anatomy and Physiology
      Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE