Accession Number : AD0684364

Title :   POTENTIAL ANTIMALARIALS STRUCTURALLY RELATED TO QUININE.

Descriptive Note : Annual rept. no. 1, 1 Jan-31 Dec 68,

Corporate Author : COLORADO UNIV BOULDER

Personal Author(s) : Coffen,David L.

Report Date : 07 FEB 1969

Pagination or Media Count : 35

Abstract : The base-catalyzed condensation of 3-quinuclidinone with quinoline carboxaldehydes provides easy access to a large number of compounds which may be loosely described as desvinylquinine derivatives. Many such substances have been synthesized and submitted for antimalarial screening. Of particular interest are the quinolinemethanols obtained by acid-catalyzed hydration of the condensation products. The unique metal complexes of 2-(2'-quinolyl)methylene-3-quinuclidinone which were encountered during this work and progress on an attempt to synthesize the complete quinine skeleton are also described. (Author)

Descriptors :   (*ANTIMALARIALS, *CINCHONA ALKALOIDS), (*QUINOLINES, SYNTHESIS(CHEMISTRY)), (*COMPLEX COMPOUNDS, QUINOLINES), STEREOCHEMISTRY, ADDITION REACTIONS, KETONES, CONDENSATION REACTIONS, ALCOHOLS, COPPER COMPOUNDS, NICKEL COMPOUNDS, COBALT COMPOUNDS, CHLORINE COMPOUNDS

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE