Accession Number : AD0685464

Title :   STUDIES ON MAMMALIAN AND HUMAN PYRUVATE AND ALPHA-KETOGLUTARATE DEHYDROGENATION COMPLEXES.

Descriptive Note : Progress rept.,

Corporate Author : NAGASAKI UNIV (JAPAN) ATOMIC DISEASE INST

Personal Author(s) : Koike,Masahiko

Report Date : SEP 1968

Pagination or Media Count : 18

Abstract : The aims of the project are to resolve the pig heart pyruvate and alpha-ketoglutarate dehydrogenase complexes into their essential constituent enzymes, to characterize the latter, and to determine the composition and macromolecular structure of these two multienzymes. Attempts will be made to locate these multienzyme units in the mitochondrial membrane by using ferritin-antibody against lipoamide dehydrogenase. Finally, these studies will be extended to the alpha-keto acid dehydrogenase systems of human heart and other organs. (Author)

Descriptors :   (*PYRUVATES, OXIDATION), (*OXIDOREDUCTASES, CHEMICAL ANALYSIS), OXIDOREDUCTASES, SWINE, HEART, TRANSFERASES, CHEMICAL REACTIONS, LIPIDS, ELECTROPHORESIS, TABLES(DATA), JAPAN

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE