Accession Number : AD0685475

Title :   THE ORIGIN OF THE URINARY PEPTIDE HYDROXYPROLINE IN BURNS,

Corporate Author : HOSPITAL FOR SICK CHILDREN TORONTO (ONTARIO) DIV OF BIOCHEMISTRY RESEARCH

Personal Author(s) : Jackson,S. H. ; Elliott,T. G.

Report Date : 04 OCT 1968

Pagination or Media Count : 7

Abstract : A double labelling method, using (3H) and (14C)proline, has been used to study the origin of the increased urinary peptide hydroxyproline excretion in rats receiving an experimental burn. The excretion of total hydroxyproline follows a biphasic pattern with an initial elevation, a return to normal, and then a prolonged elevation. During the initial elevation the hydroxyproline originates from a collagen 'pool' with a rapid metabolism. During the second elevation it comes from generalized catabolism of 'mature' collagen. There was no evidence that the peptide hydroxyproline came from resorption of collagen at the burn site itself. Burning did not stimulate the synthesis of new collagen. (Author)

Descriptors :   (*BURNS(INJURIES), *AMINO ACIDS), RADIOACTIVE ISOTOPES, LABELED SUBSTANCES, PEPTIDES, EXCRETION, METABOLISM, COLLAGEN, BIOSYNTHESIS, RATS, CANADA

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE