Accession Number : AD0685814

Title :   DETOXICATION OF A PURIFIED AND CONCENTRATED DIPHTHERIA TOXIN BY FORMALIN,

Corporate Author : ARMY FOREIGN SCIENCE AND TECHNOLOGY CENTER WASHINGTON D C

Personal Author(s) : Larionova,L. V. ; Vasilev,N. N. ; Vorobev,A. A. ; Kalinskaya,N. A. ; Chevotareva,S. V.

Report Date : FEB 1969

Pagination or Media Count : 14

Abstract : Results are presented from a study of the preparation of purified and concentrated diphtheria anatoxin by detoxication of purified toxin. Acid precipitation was used to purify the toxin. Loss of activity in the supernatant fluid and the precipitate did not exceed 8-10%. Depigmented, sterile solutions of purified diphtheria toxin were used for further study of conditions of detoxication, including the role of pH in the conversion of purified toxin to anatoxin. The most favorable results of detoxication were obtained at pH 7.0-7.2. (Author)

Descriptors :   (*CORYNEBACTERIUM DIPHTHERIAE, *DETOXIFICATION), (*FORMALDEHYDE, DETOXIFICATION), VACCINES, DISEASES, PREPARATION, PURIFICATION, CONCENTRATION(CHEMISTRY), PH FACTOR, USSR

Subject Categories : Microbiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE