Accession Number : AD0687081

Title :   RESPONSE OF A SPECIFIC GLUCOCORTICOID-MEDIATED GLYCOPROTEIN (Alpha-2-GP) TO IRRADIATION INJURY,

Corporate Author : MASON RESEARCH INST WORCESTER MASS DEPT OF IMMUNOLOGY

Personal Author(s) : Bogden,Arthur E.

Report Date : DEC 1968

Pagination or Media Count : 26

Abstract : Use of a monospecific antiserum reagent permitted detection and quantitation of an alpha-2 glycoprotein (alpha-2-GP) in the serum of rats subjected to increasing doses of whole-body x-irradiation. It was found that (a) irradiation injury induced synthesis of this specific glycoprotein macroglobulin, (b) serum alpha-2-GP levels showed a dose-response relationship, and (c) cortisol administration following irradiation had an enhancing effect on alpha-2-GP response. Tissue injury resulting from x-irradiation appeared to evoke the same mechanisms of alpha-2-GP response as physical or chemical forms of trauma. Results of a preliminary probe indicated that the apparent dose rate effects may be a reflection of 'restraint' stress with resultant response variations due to endogenous glucocorticoid release. Ancillary studies, designed to use the alpha-2-GP response as an indirect measure of the humoral factor (designated HIS) responsible for initiation of hepatic synthesis of alpha-2-GP, revealed that serum prepared from normal, nontraumatized animals, in contrast to plasma from the same source, could stimulate hepatic synthesis of alpha-2-GP when administered to normal, nontraumatized animals. The rationale for utilizing HIS release as a biodosimeter for estimating irradiation injury is discussed. (Author)

Descriptors :   (*GLYCOPROTEINS, *RADIATION EFFECTS), (*IMMUNE SERUMS, GLYCOPROTEINS), (*IMMUNOLOGY, RADIATION EFFECTS), X RAYS, NEOPLASMS, BLOOD SERUM, RADIOBIOLOGY

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE