Accession Number : AD0687378

Title :   RADIOKINETIC STUDY OF WR-6798 GIVEN AS A SINGLE 1600 mg DOSE CONTAINING 100 MICROGRAMS OF 35S IN CONJUNCTION WITH ONE STANDARD C/P TABLET TO HEALTHY POSTMENOPAUSAL VOLUNTEERS.

Descriptive Note : Rept. no. 2 (Final),

Corporate Author : OKLAHOMA STATE PENITENITARY MCALESTER

Personal Author(s) : Colmore,John P. ; Desper,Paul C. ; Vloedman,D. A. , Jr

Report Date : 08 APR 1969

Pagination or Media Count : 24

Abstract : Five healthy adult post-menopausal female volunteers were each given a single dose of 1600 mg of WR-6798-35S (containing 100 microcuries of 35S) together with a single standard chloroquine/primaquine tablet, with urine, stool, plasma and red blood cell collections made both prior to and over the period of the ensuing 13 days. One subject developed clinical cyanosis with symptoms compatible with anemia and was found to have significant methemeglobinemia (32% of her total hemoglobin was in this form). No treatment was given and she recovered spontaneously over the course of the next several days. No reduction in G-6PD, 6 phosphogluconic dehydrogenase, glutathione reductase nor methemoglobin reductase values could be demonstrated. The results of the radioactivity determinations (done elsewhere) were not available at the time of the preparation of this report. (Author)

Descriptors :   (*ANTIMALARIALS, METABOLISM), CINCHONA ALKALOIDS, BLOOD PLASMA, URINE, BLOOD ANALYSIS, ENZYMES, TOXICITY, PATHOLOGY, FEMALES, CHEMOTHERAPEUTIC AGENTS, ORGANIC SULFUR COMPOUNDS, AMINES, ALDEHYDES

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE