Accession Number : AD0687528

Title :   SYNTHESIS OF THE NATURALLY OCCURRING PHYTANYL DIETHER ANALOGS OF PHOSPHATIDYL GLYCEROPHOSPHATE AND PHOSPHATIDYL GLYCEROL,

Corporate Author : NATIONAL RESEARCH COUNCIL OF CANADA OTTAWA (ONTARIO) DIV OF BIOSCIENCES

Personal Author(s) : Joo,C. N. ; Kates,M.

Report Date : 03 OCT 1968

Pagination or Media Count : 20

Abstract : The diastereomers of the diphytanyl glycerol ether analogs of phosphatidyl glycerophosphate and phosphatidyl glycerol have been synthesized chemically and compared with the respective natural isomer isolated from the extremely halophilic bacterium, Halobacterium cutirubrum. The structure and configuration of the natural isomer of the phosphatidyl glycerophosphate was thus shown to be 2,3-di-O-(3'R,7'R,11'R,15-tetramethylhexadecyl)-sn-glycero-1-phosphoryl-3' -sn-glycero-1'phosphate; the natural phosphatidyl glycerol was shown to have the structure and configuration, 2,3-di-O-(3'R,7'R,11'R, 15-tetramethylhexadecyl)-sn-glycero-1-phosphoryl-3'-sn-glycerol. The implications of these findings on the biosynthetic mechanisms for these unusual phosphatides are discussed. (Author)

Descriptors :   (*PHOSPHOLIPIDS, SYNTHESIS(CHEMISTRY)), GLYCEROLS, PHOSPHATES, ETHERS, CANADA, BACTERIA

Subject Categories : Biochemistry
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE