Accession Number : AD0687654

Title :   GAMMA-RADIOLYSIS OF DISULFIDES IN AQUEOUS SOLUTION. II. D-PENICILLAMINE DISULFIDE,

Corporate Author : DEFENSE RESEARCH ESTABLISHMENT OTTAWA (ONTARIO)

Personal Author(s) : Purdie,J. W.

Report Date : 10 JUL 1968

Pagination or Media Count : 9

Abstract : The gamma-radiolysis of D-penicillamine disulfide (PenSSPen) in an aqueous solution has been studied under aerated and deaerated conditions. G values were determined for the following products: penicillamine sulfinic acid (PenSO2H), penicillaminic acid (PenSO3H), beta-hydroxyvaline (PenOH), 2-amino-3-methylbut-3-enoic acid (HOOC.CH(NH2).C(CH3)=CH2), penicillamine (PenSH), penicillamine disulfide-S-monoxide (PenS(O)SPen), valine (PenH), penicillamine trisulfide (PenSSSPen), and ammonia. The low yield of PenSO3H in aerated solution indicated that PenSOH did not react with oxygen or O2(-). Experiments with OH radicals produced chemically (TiCl3/H2O2) and irradiations with cysteine or penicillamine present were used to confirm these reactions. These and the other reactions were tested with radical scavengers; formate and monochloroacetate ions and nitrous oxide. (Author)

Descriptors :   (*SULFIDES, *RADIATION CHEMISTRY), FREE RADICALS, AMINO ACIDS, ORGANIC SULFUR COMPOUNDS, CANADA

Subject Categories : Biochemistry
      Radiation and Nuclear Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE