Accession Number : AD0688130

Title :   A RATIONALE FOR THE PREPARATION OF NONTHROMBOGENIC MATERIALS.

Descriptive Note : Technical rept.,

Corporate Author : WALTER REED ARMY MEDICAL CENTER WASHINGTON D C ARMY MEDICAL BIOMECHANICAL RESEARCH LAB

Personal Author(s) : Leonard,Fred

Report Date : APR 1969

Pagination or Media Count : 11

Abstract : It is postulated that negative charges, per se, are insufficient to impart thromboresistance to a polymer surface. Rather, it is hypothesized that a specific steric array of negative charges is required; certain distribution favoring thromboresistance and others either not imparting thromboresistance or, indeed, enhancing the possibility of thrombus formation. The distances between charges required may be a function of whether an intramolecular calcium bridge may be formed. It is proposed that truly neutral surfaces may be more suitable as thromboresistant surfaces. (Author)

Descriptors :   (*POLYMERS, *BLOOD COAGULATION), (*ANTICOAGULANTS, SURFACE PROPERTIES), (*SURGICAL IMPLANTATION, ANTICOAGULANTS), THEORY, IONS, BLOOD PLATELETS, CALCIUM, ADENOSINE PHOSPHATES, ADSORPTION, SULFONATES, STYRENE PLASTICS

Subject Categories : Biochemistry
      Medical Facilities, Equipment and Supplies

Distribution Statement : APPROVED FOR PUBLIC RELEASE