Accession Number : AD0688253

Title :   A PRELIMINARY INVESTIGATION OF THE EFFECT OF REPEATED LOW DOSES OF MONOMETHYLHYDRAZINE ON OPERANT BEHAVIOR OF PRIMATES,

Corporate Author : AEROMEDICAL RESEARCH LAB (6571ST) HOLLOMAN AFB N MEX

Personal Author(s) : Whitney,Glayde D. ; Taylor,Henry L. ; Johnson,Duane R. ; Batson,Paul Y.

Report Date : MAR 1969

Pagination or Media Count : 20

Abstract : The rocket fuel monomethylhydrazine (MMH) is known to have severe disruptive effects on learned behavior. Behavioral toxicity, measured as decrement in instrumental performance, has been found following dosages of 2.5 mg/kg or more. This experiment was designed to explore effects on behavior of doses lower than those previously studied, and to investigate possible cumulative behavioral effects or repeated exposures to low concentrations of MMH. Monkeys performing a learned instrumental avoidance task requiring continual discrimination of cues were given repeated injections of MMH at four dose levels ranging from 0.5 mg/kg to 4.0 mg/kg. The results indicate that exposure to low doses may result in highly significant behavioral stimulation. Indications of a cumulative effect from repeated exposure on behavior are noted. Cumulative effects and increases in rate of performance following exposure to these doses may indicate important behavioral toxicity of MMH at dose levels lower than those previously considered. (Author)

Descriptors :   (*METHYL HYDRAZINES, *TOXICITY), (*BEHAVIOR, *LIQUID ROCKET FUELS), DOSAGE, PRIMATES

Subject Categories : Psychology
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE