Accession Number : AD0688374

Title :   RADIOPROTECTION OF RODENTS WITH PAPAIN.

Descriptive Note : Rept. for Sep 67-Sep 68,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Hamilton,Horace E. ; Melville,George S. , Jr. ; Moss,Shirley A.

Report Date : MAR 1969

Pagination or Media Count : 14

Abstract : The proteolytic enzyme papain was demonstrated to be moderately radioprotective in rats. The enzyme was administered intraperitoneally both activated and nonactivated in water, in a water-dimethyl sulfoxide solvent system. Greater survival was achieved with the activated form in the H2O-DMSO solvent; administered by this method thirty minutes prior to 1200 roentgens gamma radiation delivered at a dose rate of 400 R/minute, 50% survival was obtained at a papain dose of 43.2 milligrams per kilogram rodent weight. The optimum time of injection was found to be in the interval 10 to 20 minutes prior to irradiation. Administered in water, the enzyme induced an initial radiation-sensitizing effect, but this was not noted when the dimethyl sulfoxide was utilized. (Author)

Descriptors :   (*RADIOPROTECTIVE AGENTS, *PAPAIN), (*RODENTS, RADIOPROTECTIVE AGENTS), SURVIVAL(PERSONNEL), GAMMA RAYS, SENSITIVITY, SULFOXIDES, DOSAGE

Subject Categories : Radiobiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE