Accession Number : AD0688872

Title :   HUMAN ERYTHROCYTE MEMBRANE UPTAKE OF PROGESTERONE AND CHEMICAL ALTERATIONS.

Descriptive Note : Interim rept.,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : DeVenuto,Frank ; Ligon,Dorothy F. ; Friedrichsen,Don H. ; Wilson,Harold L.

Report Date : 28 FEB 1969

Pagination or Media Count : 23

Abstract : A program was undertaken to explore the mechanism of action of progesterone in relation to the preservation of red blood cells and to establish a possible effect of progesterone on the alterations of the chemical composition of the cell membrane during storage of blood. Progesterone shows a definite interaction with soluble protein components of the red cell membrane and the combining affinity is greater at 37 than at 4C. Differences are observed in the chemical composition and in the uptake of progesterone using membrane preparations obtained from fresh or 42-day old blood of male and female donors. A great loss of phospholipid content and a significant loss of sialic acid occur in the membrane of red cells from blood of male donors after 42 days storage under blood banking conditions. (Author)

Descriptors :   (*PROGESTERONE, ERYTHROCYTES), (*ERYTHROCYTES, PRESERVATION), (*MEMBRANES(BIOLOGY), PROGESTERONE), TEMPERATURE, HUMANS, MALES, FEMALES, PHOSPHOLIPIDS, PROTEINS, CARBOHYDRATES, CHEMICAL ANALYSIS, BLOOD CHEMISTRY, CELL WALL

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE