Accession Number : AD0689630

Title :   CORRELATION BETWEEN DECREASES IN BRAIN GAMMA-AMINOBUTYRIC ACID LEVELS AND SUSCEPTIBILITY TO CONVULSIONS INDUCED BY HYPERBARIC OXYGEN,

Corporate Author : DEFENCE RESEARCH ESTABLISHMENT TORONTO DOWNSVIEW (ONTARIO)

Personal Author(s) : Wood,J. D. ; Watson,W. J. ; Murray,G. W.

Report Date : 27 MAY 1968

Pagination or Media Count : 8

Abstract : The susceptibility of mice to seizures at hyperbaric pressures of oxygen (OHP) was placed on a quantitative basis and compared with the corresponding rate of decrease in brain GABA concentration. The influence of small amounts of carbon dioxide in the breathing mixture on these effects of OHP was also determined. A correlation between the rate of decrease in GABA and susceptibility to seizures was shown to exist not only over the varying oxygen pressures and varying concentrations of carbon dioxide used in the present experiments but also over varying animal species (a previous study). The critical oxygen pressure for decreases in brain GABA to occur was shown to be 30 p.s.i.g. This value agreed closely with the well documented critical pressure necessary to produce seizures in both animals and man. The probability that lowered brain GABA levels play a major role in the etiology of OHP convulsions was discussed. (Author)

Descriptors :   (*BRAIN, FATTY ACIDS), (*FATTY ACIDS, CONVULSIVE DISORDERS), OXYGEN, CARBON DIOXIDE, CONCENTRATION(CHEMISTRY), BAROMETRIC PRESSURE, RATS, TISSUES(BIOLOGY), AMINO ACIDS, POISONING, CONVULSIVE DISORDERS, CANADA

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE