Accession Number : AD0690212

Title :   EFFECTS OF ALTITUDE ON CELLULAR METABOLISM AND TERMINAL OXIDATION.

Descriptive Note : Annual rept. no. 1, 15 Apr 68-14 Apr 69,

Corporate Author : HOWARD UNIV WASHINGTON D C DEPT OF PHYSIOLOGY

Personal Author(s) : Costello,Leslie C. ; Gold,Armand J.

Report Date : JUN 1969

Pagination or Media Count : 16

Abstract : The effects of high altitude exposure on cellular metabolism have not been clearly established. Of particular interest are the possible alterations in energy metabolism and oxidative pathways resulting from such exposure. The present report is concerned with some initial studies of the effects of altitude on mitochondrial activity. Rats were exposed to 0.5 atmosphere in an altitude chamber for 6-7 days. Such exposure resulted in a 25% increase in hematocrit readings. The animals lost weight as compared to controls. Altitude exposure resulted in a significant increase in plasma pyruvate values. Plasma citrate levels were not consistently altered. Such results indicated a physiological and biochemical response to the hypobaric exposure. Cytochrome c oxidase activity of mitochondria from liver, kidney, heart, and skelatal muscle was ascertained. The results to date indicate that cytochrome oxidase activity was not significantly altered. (Author)

Descriptors :   (*HIGH ALTITUDE, *METABOLISM), CELLS(BIOLOGY), HYPOXIA, EXPOSURE(PHYSIOLOGY), MITOCHONDRIA, HEMATOCRIT, BODY WEIGHT, BAROMETRIC PRESSURE, TISSUES(BIOLOGY), OXIDATION, OXIDOREDUCTASES

Subject Categories : Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE