Accession Number : AD0690214

Title :   CHEMISTRY AND BIOLOGICAL ACTIVITY OF LEUCOGENENOL.

Descriptive Note : Final rept.,

Corporate Author : AMERICAN UNIV WASHINGTON D C DEPT OF CHEMISTRY

Personal Author(s) : Rice,Frederick A. H. ; Barrow,Meredith ; Shaikh,B.

Report Date : 31 MAY 1968

Pagination or Media Count : 10

Abstract : Leucogenenol was isolated from the metabolic products of Penicillium gilmanii grown on a Czapek Dox medium. It was isolated on the basis that it was the compound responsible for the leukocytosis observed following the intravenous injection of the culture medium of P. gilmanii into rabbits. The compound is of relatively low molecular weight and does not cause a febrile response. After the isolation of leucogenenol, studies demonstrated that the compound is produced as such by growing cultures of P. gilmanii and then diffuses into the culture medium. Further studies showed that leucogenenol stimulated the formation of the precursors of the peripheral leukocyte, particularly the myeloblast and the lymphoblast. Whether or not other cells are affected is not known. Probably as a consequence of the stimulation of cell formation by leucogenenol, mice whose myeloid and lymphoid tissues had been damaged by x-radiation recovered more rapidly when injected with leucogenenol than did the untreated controls. Leucogenenol was found to be a normal constituent of beef and human liver. This finding suggests the interesting probability that leucogenenol functions normally as a compound that plays a role in the production and regulation of leukocytes and possibly other cells in the body. (Author)

Descriptors :   (*PENICILLIUM(PENICILLINS), METABOLISM), (*LEUKOCYTES, DEGRADATION), CULTURE MEDIA, BLOOD CELLS, GROWTH(PHYSIOLOGY), CYTOLOGY, RADIATION EFFECTS, RECOVERY, MICE, LIVER, BLOOD CHEMISTRY, BLOOD ANALYSIS

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE