Accession Number : AD0690217

Title :   CYANOACRYLATE ADHESIVES IN EYE WOUNDS.

Descriptive Note : Annual progress rept. 1 Sep 68-1 Jun 69,

Corporate Author : RETINA FOUNDATION BOSTON MASS DEPT OF CORNEA RESEARCH

Personal Author(s) : Refojo,Miguel F.

Report Date : 01 JUN 1969

Pagination or Media Count : 14

Abstract : Three main sets of experiments are described in this report: (1) tolerance of cyanocacrylate adhesives in rabbit eyes; (2) in vitro tensile strength of corneal stroma-stroma and sclera-silicone rubber adhesive joints; and (3) sealing corneal and choroidal perforations and lacerations with adhesives. The following adhesives were tested: methyl, isobutyl, n-butyl, n-hexyl, n-heptyl, n-octyl, n-decyl, -trifluoroisopropyl 2-cyanoacrylate, and Biobond. Of these, methyl and -trifluoroisopropyl cyanoacrylates are not well tolerated by eye tissues. Biobond sets too slowly, and does not seem useful for the treatment of eye perforations. Any of the other adhesives tested could be employed to seal both corneal and scleral wounds. Isobutyl 2-cyanoacrylate is the best adhesive found so far when tissue tolerance, tensile strength, and ability to seal eye perforations (alone and with silicone rubber patches) are the criteria. (Author)

Descriptors :   (*ACRYLIC RESINS, DRESSINGS), (*ADHESIVES, DRESSINGS), (*EYE, DRESSINGS), WOUNDS AND INJURIES, TISSUES(BIOLOGY), TOLERANCES(PHYSIOLOGY), THERAPY, PLASTICS, TENSILE PROPERTIES

Subject Categories : Medical Facilities, Equipment and Supplies
      Plastics

Distribution Statement : APPROVED FOR PUBLIC RELEASE