Accession Number : AD0690576

Title :   CARCINOGENESIS IN THE LUNG FROM INHALATION OF RADIOACTIVE PARTICLES.

Descriptive Note : Final rept.,

Corporate Author : BATTELLE-NORTHWEST RICHLAND WASH PACIFIC NORTHWEST LAB

Personal Author(s) : Sanders,Charles L. ; Thompson,Roy C. ; Bair,W. J.

Report Date : MAY 1969

Pagination or Media Count : 80

Abstract : Consideration is given to the information available as to size and radioactivity of particles which might be produced in the testing or space application of uranium fueled reactors; the information available on the probability of deposition and retention in the lung of such particles, if inhaled; the information available from a variety of animal studies on the carcinogenic potential of radioactive materials deposited in the lung. This information is not sufficient to define the hazard with any degree of confidence, however, a model was derived which purports to estimate the carcinogenic risk associated with variously sized and activated particles from uranium fueled reactors. Based on this model it was concluded that where the exposed people, the risks involved appear to be acceptable risks. The model is of no predictive value where large numbers of people may be exposed and where low incidence effects become significant. Studies are described, and urgently recommended, which could lead to a better understanding of the mechanism of radiation-induced tumor formation in the lung. (Author)

Descriptors :   (*CANCER, *LUNG), (*RADIATION EFFECTS, CANCER), URANIUM, THRESHOLDS(PHYSIOLOGY), RADIATION DOSAGE, RADIATION HAZARDS, PREDICTIONS, SPACECRAFT NUCLEAR PROPULSION, REACTOR FUELS

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE