Accession Number : AD0690750

Title :   THE EFFECT OF HYPERBARIC OXYGEN ON METABOLISM OF THE GABA SHUNT.

Descriptive Note : Technical note,

Corporate Author : DEFENCE RESEARCH ESTABLISHMENT TORONTO DOWNSVIEW (ONTARIO)

Personal Author(s) : Myles,W. S. ; Wood,J. D.

Report Date : 13 AUG 1968

Pagination or Media Count : 5

Abstract : The GABA-alpha-ketoglutarate transaminase pathway provides, in the brain, an alternative route for the conversion of alpha-ketoglutarate to succinate. In vitro experiments with rat brain homogenates and either (14C)GABA or (14C)alpha-ketoglutarate showed the percentage metabolism via the transaminase pathway to be about 17 per cent in air and 10 per cent oxygen at high pressure. Since the transaminase shunt was more sensitive to hyperbaric oxygen than the direct pathway, these results do not support the hypothesis of an alternative route operating under conditions of oxygen poisoning. (Author)

Descriptors :   (*BRAIN, *OXYGEN), (*METABOLISM, BRAIN), ENZYMES, CARBOXYLIC ACIDS, SUCCINATES, PRESSURE, CANADA

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE