Accession Number : AD0690855

Title :   PHYSICOCHEMICAL TISSUE CHANGES FOLLOWING IRRADIATION.

Descriptive Note : Final rept. Jul 58-Jun 69,

Corporate Author : CONSULTANTS INTERNATIONAL INC DALLAS TEX

Personal Author(s) : Reynolds,B. L.

Report Date : AUG 1969

Pagination or Media Count : 16

Abstract : Whole body irradiation (WB1) produces scopal and abscopal effects in albino rats. Primary scopal events are deploymerization of interstitial substance (1SW) mucoprotein, with increases in acid, free water and in destruction of mobile cells of 1 SW (erythrocytes; leukocytes; histiocytes; plasma cells). Membranes resistant to water perfusion form in 1SW, and may proceed to frank fibrosis, depending upon quality and quantity of WB1. Abscopal effects follow dissemination of scopal physiocochemical agents, and affect, particularly, brain, heart, lung, kidney, and gastro-intestinal tract. Iatrogenic alteration of the 1SW is possible, for reduction of scopal effects of WB1, hence, abscopal perfusion. Results of our experiences with these alterations are presented. (Author)

Descriptors :   (*TISSUES(BIOLOGY), *RADIATION EFFECTS), BONE MARROW, WHOLE BODY IRRADIATION, MEMBRANES(BIOLOGY), BLOOD CELLS, PATHOLOGY, PERMEABILITY, BRAIN, HEART, LUNG, KIDNEYS, RADIATION DOSAGE

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE