Accession Number : AD0690858

Title :   CHELATED TRACE METALS IN WOUND REPAIR.

Descriptive Note : Annual progress rept. no. 1, 1 Jun 68-30 May 69,

Corporate Author : GEORGETOWN UNIV WASHINGTON D C

Personal Author(s) : Rubin,Martin I. ; Silverman,Steven A.

Report Date : 30 JUN 1969

Pagination or Media Count : 40

Abstract : The ability of a variety of metal binding agents to modify the distribution of injected zinc in guinea pigs was studied. After the formation of a standardized bone wound the subsequent deposition of the metal was measured in the healing tissue, the uninjured bone areas and in other organs. The experimental design included treatment with saline and zinc sulfate as controls. The studies established the possibility of controlled removal of zinc from healing tissue and its selective deposition in regenerating areas by choice of the appropriate ligands. Calcium disodium diethylenetriamine pentaacetic acid effectively causes removal of tissue zinc. Contrastingly, 2,3-dimercaptopropane sulfonic acid and cysteiamine-N-acetic acid, as their zinc chelates, are the most effective agents yet identified for selective delivery of zinc to repair tissues. The experimental results, coupled with a demonstrable relative deficiency of zinc in repair tissue during wound healing, point the way to a therapeutic modality for accelerating wound repair. (Author)

Descriptors :   (*WOUNDS AND INJURIES, ZINC), (*ZINC, METABOLISM), (*CHELATE COMPOUNDS, WOUNDS AND INJURIES), HEALING, THERAPY, TISSUES(BIOLOGY), ACETIC ACID, SULFONIC ACIDS

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE