Accession Number : AD0690991

Title :   A MATHEMATICAL MODEL OF THE CHEMICAL DISTRIBUTION IN A DISEASE STATE: HYPOTHYROIDISM,

Corporate Author : RAND CORP SANTA MONICA CALIF

Personal Author(s) : Wolf,M. B. ; DeLand,E. C. ; Maloney,J. V. , Jr

Report Date : JUN 1969

Pagination or Media Count : 68

Abstract : Models of fluid and electrolyte distribution in a standard (euthyroid) dog and a hypothyroid dog were developed. The model of the euthyroid dog was altered by adding a new fluid compartment, Colloid, to conform to a hypothesis of body chemistry changes in hypothyroid animals as determined from the literature. Both euthyroid and hypothyroid laboratory dogs received injections of acid solution to provide chemical data for comparing chemical distribution and for validating the models simulating these states. The results proved statistically that hypothyroid dogs respond differently from normal ones to acid infusion. However, the hypothyroid model did not predict these experimental results well. Although laboratory technological problems accounted for many of these discrepancies, additional experiments and other chemical perturbations are necessary to test the biochemical hypotheses formulated in this study. (Author)

Descriptors :   (*THYROID GLAND, DISEASES), (*DISEASES, MATHEMATICAL MODELS), DOGS, BODY FLUIDS, ELECTROLYTES(PHYSIOLOGY), CHEMICAL ANALYSIS, PHYSIOLOGY, COMPUTERS, SIMULATION

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE